Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Spring;10(2):265-71.

Chemical Compositionand Anti-acetyl cholinesterase Activity of Flower Essential Oils of Artemisiaannuaat Different Flowering Stage

Zhengwen Yu  1 , Bochu Wang, Fumei Yang, Qianyun Sun, Zhannan Yang, Liancai Zhu
Affiliations

Chemical Compositionand Anti-acetyl cholinesterase Activity of Flower Essential Oils of Artemisiaannuaat Different Flowering Stage

Zhengwen Yu et al. Iran J Pharm Res. 2011 Spring.

Abstract

The chemical composition of the essential oils of flower at the pre-flowering, full-flowering and post-flowering stage of A. annua was analyzed by GC and GC/MS and sixty-two components were identified. The main compounds in the pre-flowering oil were β-myrcene (37.71%), 1, 8-cineole (16.11%) and camphor (14.97%). The full-flowering oil contained predominantly caryophyllene (19.4%), germacrene D (18.1%), camphor (15.84%), 1, 8-cineole (10.6%) and (Z)-β-farnesene (9.43%). The major constituents identified in the post-flowering oil were camphor (16.62%), caryophyllene (16.27%), β-caryophyllene oxide (15.84%), β-farnesene (9.05%) and (-)-spathulenol (7.21%). The variety of anti-AChE activity of flower oil of A. annua at three flowering stage might be a result of the variety of the content and interaction of those terpenoids with anti-AChE activity. The greatest acetylcholinesterase inhibitory activity (IC50 = 0.13 ± 0.02 mg mL(-1)) was exhibited by the essential oil of flower of A. annua at post-flowering stage.

Keywords: Anti-acetylcholinesterase activity; Artemisia annua; Essential oils.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The change of the content of the monoterpenes and sesquiterpenes from pre-flowering to post-flowering stage
See this image and copyright information in PMC

References

    1. Bertea CM, Freije JR, Van der Woude, Verstappen FW, Perk L, Marquez V, De Kraker JW, Posthumus MA, Jansen BJ, de Groot A, Franssen MC, Bouwmeester HJ. Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. Planta Med. 2005;71:40–47. - PubMed
    1. Brown GD, Liang GY, Sy LK. Terpenoids from the seeds of Artemisia annua L. Phytochem. 2003;64:303–323. - PubMed
    1. Klayman DL. Qinghaosu (artemisinin): an antimalarial drug from China. Science. 1985;228:1049–1055. - PubMed
    1. Bhakuni RS, Jain DC, Sharma RP, Kumar S. Secondary metabolites of Artemisia annua and their biological activity. Cur. Sci. 2001;80:35–48.
    1. Johnson N, Davis T, Bosanquet N. The epidemic of Alzheimer’s disease; how can we manage the costs? Pharmacoeconomics. 2000;18:215–223. - PubMed

LinkOut - more resources