Studies on Flowability, Compressibility and In-vitro Release of Terminalia Chebula Fruit Powder Tablets

Abstract

The dried fruit of Terminalia chebula is widely used for its laxative properties. The objective of the present study was to examine the flowability and compressibility of Terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. Initial studies on flowability and compressibility revealed that the fruit powder flows poorly, is poorly compressible and mucilaginous in nature. The consolidation behaviors of the fruit powder and of its tablet formulations were studied using the Kawakita, Heckel and Leuenberger equations. Kawakita analysis revealed reduced cohesiveness hence improved flowability was achieved in formulations prepared by direct compression and the wet granulation technique. The Heckel plot showed that the Terminalia chebula fruit powder when formulated using direct compression showed initial fragmentation followed by plastic deformation and that the granules exhibited plastic deformation without initial fragmentation. The compression susceptibility parameter obtained from the Leuenberger equation for compacts formed by using the direct compression and wet granulation techniques indicated that the maximum crushing strength is reached faster and at lower compression pressures. The Tannin content (with reference to standard tannin) in fruit powder and tablet formulations was determined by UV spectrophotometry at 273 nm. The in-vitro dissolution study in simulated SGF (without enzymes) showed more than a 90% release of tannin from the tablets with in 1 h. The brittle fracture index value revealed that tablets prepared from granules showed less fracture tendency in comparison to those formed by direct compression formulation. From this study, it was concluded that the desired flowability, compressibility and compactibility of Terminalia chebula fruit powder can be obtained by using the direct compression and wet granulation techniques.

Keywords: Compressibility; Dissolution; Flowability; Tablet; Terminalia chebula.

Figure 1

Heckel plot for Terminalia chebula fruit powder and its formulations

Figure 2a

The radial crushing strength was plotted against the product of the pressure of compression and the relative density of Terminalia chebula fruit powder

Figure 2b

The radial crushing strength was plotted against the product of the pressure of compression and the relative density of Terminalia chebula fruit direct compression formulation

Figure 2c

The radial crushing strength was plotted against the product of the pressure of compression and the relative density of the Terminalia chebula fruit granules

Figure 3

Dissolution profile of tablets prepared by the wet granulation method (Tablet WG) and direct compression method (Tablet DC) in Simulated gastric fluid (SGF