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. 2011;3(4):117-22.
doi: 10.5681/jcvtr.2011.026. Epub 2011 Dec 28.

Therapeutic potential of umbilical cord blood stem cells on brain damage of a model of stroke

Mohammad Reza Nikravesh  1 , Mehdi Jalali, Hossein Ali Ghafaripoor, Javad Sanchooli, Darioush Hamidi, Shabnam Mohammadi, Masoomeh Seghatoleslam
Affiliations

Therapeutic potential of umbilical cord blood stem cells on brain damage of a model of stroke

Mohammad Reza Nikravesh et al. J Cardiovasc Thorac Res. 2011.

Abstract

Introduction: Human cord blood-derived stem cells are a rich source of stem cells as well as precursors. With regard to the researchers have focused on the therapeutic potential of stem cell in the neurological disease such as stroke, the aim of this study was the investiga-tion of the therapeutic effects of human cord blood-derived stem cells in cerebral ischemia on rat.

Methods: This study was carried out on young rats. Firstly, to create a laboratory model of ischemic stroke, carotid artery of animals was occluded for 30 minutes. Then, umbilical cord blood cells were isolated and labeled using bromodeoxyuridine and 2×10(5) cells were injected into the experimental group via the tail vein. Rats with hypoxic condi-tions were used as a sham group. A group of animals did not receive any injection or sur-geries were used as a control.

Results: Obtained results were evaluated based on behavioral responses and immunohistochemistry, with emphasis on areas of putamen and caudate nucleus in the control, sham and experimental groups. Our results indicated that behavioral recovery was observed in the experimental group compared to the either the sham or the control group. However, histological studies demonstrated a low percent of tissue injury in the experimental group in comparison with the sham group.

Conclusion: Stem cell transplantation is beneficial for the brain tissue reparation after hypoxic ischemic cell death.

Keywords: Brain Damage; Stem Cell; Stroke; Umbilical Cord Blood.

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Conflict of interest statement

Conflict of interests: The authors declare no conflicts of interest.

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References

    1. Zivin JA, Choi DW. Stroke therapy. Sci Am . 1991; 265:56–63. - PubMed
    1. Bliss T, Guzman R, Daadi M, Steinberg GK. Cell transplantation therapy for stroke. Stroke . 2007; 38:817–26. - PubMed
    1. Schouten JW, Fulp CT, Royo NC, Saatman KE, Watson DJ, Snyder EY. A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury. J Neurotrauma . 2004; 21:1501–38. - PubMed
    1. Harris DT. Cord blood stem cells: A review of potential neurological applications. Stem Cell Rev . 2008; 4:269–74. - PubMed
    1. Ormerod BK, Palmer TD, Caldwell MA. Neurodegeneration and cell replacement. Philos Trans R Soc Lond B Biol Sci . 2008; 363:153–70. - PMC - PubMed

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