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. 2013 Oct;17(Suppl 1):S114-6.
doi: 10.4103/2230-8210.119523.

Central pontinemyelinosis, hyperparathyroidism, hypokalemia

Shyam Kishore  1 , D Kandasamy, Viveka P Jyotsna
Affiliations

Central pontinemyelinosis, hyperparathyroidism, hypokalemia

Shyam Kishore et al. Indian J Endocrinol Metab. 2013 Oct.

Abstract

Central pontinemyelinolysis (CPM) is one of the rare non-inflammatory demyelinating diseases of the pons and very rarely it can involve extrapontine structure as well. The exact etiopathogenesis of this condition is still unclear. Rapid correction of hyponatremia has been attributed as a most common factor, but alcoholism, malnutrition, prolonged use of diuretics, psychogenic polydipsia, post liver transplant and hypokalemia have also been attributed as a causative factor. We describe a case of hyperparathyroidism with concomitant hypercalcemia accompanied by central pontine myelinosis without hyponatremia/hyperosmolality or associated rapid corrections of sodium, which developed as a consequence of severe hypokalaemia.

Keywords: Central pontinemyelinosis; hyperparathyroidism; hypokalemia.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1a
Figure 1a
T1 weighted post contrast sequence in axial plane shows hypointense foci (arrow) in the pons with sparing of the periphery without any appreciable enhancement and FLAIR sequence in axial plane
Figure 1b
Figure 1b
T1 weighted post contrast sequence in axial plane shows a hyperintense area (arrow) in the central part of pons with characteristic sparing of periphery. The imaging findings are consistent with central pontine myelinosis
See this image and copyright information in PMC

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