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. 2013 Oct;17(Suppl 1):S142-5.
doi: 10.4103/2230-8210.119536.

Kallmann syndrome: MRI findings

Houneida Zaghouani  1 , Ines Slim, Neila Ben Zina, Najoua Mallat, Houda Tajouri, Chakib Kraiem
Affiliations

Kallmann syndrome: MRI findings

Houneida Zaghouani et al. Indian J Endocrinol Metab. 2013 Oct.

Abstract

Kallmann syndrome (KS) is a disease clinically characterized by the association of hypogonadotrophic hypogonadism and anosmia or hyposmia. It is a neuronal migration disorder. Magnetic resonance (MR) imaging is used to visualize the olfactory tracts and to evaluate the olfactory sulci. Five patients who clinically had hypogonadotrophic hypogonadism were examined by MR. Thin coronal images of the interior frontal region were used to determine presence or absence of olfactory tract and to evaluate the olfactory sulci.

Keywords: Anosmia; Kallmann syndrome; MRI; olfactory bulb.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Coronal T2-weighted MR image through the anterior fossa. Olfactory bulbs are absent, and the left olfactory sulcus is hypoplastic
Figure 2
Figure 2
Coronal T2 images through the frontal lobes demonstrate abnormal anatomy with absence of the olfactory bulbs. Olfactory sulcus, the gyrus rectus, and medial orbital gyrus are normal
See this image and copyright information in PMC

References

    1. Arkoncel ML, Arkoncel FR, Lantion-Ang FL. A case of Kallmann syndrome. BMJ Case Rep. 2011:2011. pii: bcr0120113727. - PMC - PubMed
    1. Doré C, Hardelin JP. Kallmann syndrome. Eur J Hum Genet. 2009;17:139–46. - PMC - PubMed
    1. Doraiswamy PM, Potts JM, Axelson DA, Husain MM, Lurie SN, Na C, et al. MR assessment of pituitary gland morphology in healthy volunteers: Age and gender related differences. AJNR Am J Neuroradiol. 1992;13:1295–9. - PMC - PubMed
    1. Truwit CL, Barkovich AJ, Grumbach MM, Martini JJ. MR imaging of Kallmann syndrome: A genetic disorder of neuronal migration affecting the olfactory and genital systems. AJNR Am J Neuroradiol. 1993;14:827–38. - PMC - PubMed
    1. Vogl TJ, Stemmler J, Heye B, Schopohl J, Danek A, Bergman C, et al. Kallman syndrome versus idiopathic hypogonadotropic hypogonadism at MR imaging. Radiology. 1994;191:53–7. - PubMed