Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Jul;25(4):637-41.
doi: 10.3109/14397595.2013.844303. Epub 2013 Oct 21.

Primary Sjögren's syndrome with chronic tubulointerstitial nephritis and lymphadenopathy mimicking IgG4-related disease

Mitsuhiro Kawano  1 , Yasunori Suzuki, Kazunori Yamada, Ichiro Mizushima, Masami Matsumura, Kenichi Nakajima, Masakazu Yamagishi, Yutaka Yamaguchi
Affiliations
Case Reports

Primary Sjögren's syndrome with chronic tubulointerstitial nephritis and lymphadenopathy mimicking IgG4-related disease

Mitsuhiro Kawano et al. Mod Rheumatol. 2015 Jul.

Abstract

We describe a 62-year-old woman with Sjögren's syndrome (SS) presenting with tubulointerstitial nephritis (TIN) and lymphadenopathy mimicking IgG4-related disease (IgG4-RD). Computed tomography revealed multiple swollen lymph nodes. Biopsy of the largest lymph node showed reactive lymphadenopathy with dense IgG4 positive plasma cell (IgG4 + PC) infiltration. Renal biopsy showed chronic plasma cell-rich TIN with IgG4 + PC infiltration. This case suggests that Immunoglobulin G4 immunostaining does not always support the diagnosis of IgG4-RD in the differential diagnosis between SS and IgG4-RD.

Keywords: IgG4; IgG4-related disease; Lymphadenopathy; Sjögren's syndrome; Tubulointerstitial nephritis.

PubMed Disclaimer

Comment in

Publication types

MeSH terms

Substances