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. 2014 Feb:131:64-7.
doi: 10.1016/j.jinorgbio.2013.10.019. Epub 2013 Oct 30.

In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole

Marta E López-Viseras  1 , Belén Fernández  2 , Sabine Hilfiker  3 , Cristina Sánchez González  4 , Juan Llopis González  5 , Antonio J Calahorro  6 , Enrique Colacio  1 , Antonio Rodríguez-Diéguez  1
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In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole

Marta E López-Viseras et al. J Inorg Biochem. 2014 Feb.

Abstract

A novel Zn mononuclear complex with 3-carboxy-pyrazole ligand has been prepared using conventional routes and characterized by X-ray diffraction. The structure consists of discrete neutral [Zn(C6H3N2O2)2(H2O)2] molecules held together by hydrogen interactions. This compound exhibits a potential in vivo antidiabetic activity and the in vitro toxicity can be considered negligible.

Keywords: Antidiabetic activity; Coordination compound; in vitro toxicity.

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