doi: 10.1016/j.jinorgbio.2013.10.019.
Epub 2013 Oct 30.
In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole
Affiliations
- PMID: 24252384
- DOI: 10.1016/j.jinorgbio.2013.10.019
Item in Clipboard
In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole
J Inorg Biochem.
2014 Feb.
Abstract
A novel Zn mononuclear complex with 3-carboxy-pyrazole ligand has been prepared using conventional routes and characterized by X-ray diffraction. The structure consists of discrete neutral [Zn(C6H3N2O2)2(H2O)2] molecules held together by hydrogen interactions. This compound exhibits a potential in vivo antidiabetic activity and the in vitro toxicity can be considered negligible.
Keywords: Antidiabetic activity; Coordination compound; in vitro toxicity.
© 2013.
Similar articles
-
Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.Bioorg Med Chem Lett. 2002 Aug 19;12(16):2105-8. doi: 10.1016/s0960-894x(02)00380-3. Bioorg Med Chem Lett. 2002. PMID: 12127514
-
Synthesis, hypoglycemic activity and molecular modeling studies of pyrazole-3-carbohydrazides designed by a CoMFA model.Eur J Med Chem. 2013 Nov;69:10-21. doi: 10.1016/j.ejmech.2013.07.054. Epub 2013 Aug 16. Eur J Med Chem. 2013. PMID: 23995214
-
Bis(allixinato)oxovanadium(IV) complex is a potent antidiabetic agent: studies on structure-activity relationship for a series of hydroxypyrone-vanadium complexes.J Med Chem. 2006 Jun 1;49(11):3251-6. doi: 10.1021/jm060229a. J Med Chem. 2006. PMID: 16722643
-
The pharmacology of the insulinomimetic effect of zinc complexes.Biometals. 2005 Aug;18(4):319-23. doi: 10.1007/s10534-005-3688-8. Biometals. 2005. PMID: 16158223 Review.
-
[Development research of new Zn complexes with anti-diabetic effect--structure-activity-related studies by displacement of coordination atom].Yakugaku Zasshi. 2012;132(9):1051-5. doi: 10.1248/yakushi.132.1051. Yakugaku Zasshi. 2012. PMID: 23023423 Review. Japanese.
Cited by
-
Adsorptive Capacity, Inhibitory Activity and Processing Techniques for a Copper-MOF Based on the 3,4-Dihydroxybenzoate Ligand.Molecules. 2022 Nov 21;27(22):8073. doi: 10.3390/molecules27228073. Molecules. 2022. PMID: 36432174 Free PMC article.
-
Crystal structure of trans-di-aqua-bis-(1H-pyrazole-3-carboxyl-ato-κ(2) N,O)copper(II) dihydrate.Acta Crystallogr E Crystallogr Commun. 2015 Nov 21;71(Pt 12):m232-3. doi: 10.1107/S2056989015021593. eCollection 2015 Dec 1. Acta Crystallogr E Crystallogr Commun. 2015. PMID: 26870440 Free PMC article.
-
Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State.Nutrients. 2021 Apr 11;13(4):1256. doi: 10.3390/nu13041256. Nutrients. 2021. PMID: 33920401 Free PMC article.
-
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.Molecules. 2018 Jan 12;23(1):134. doi: 10.3390/molecules23010134. Molecules. 2018. PMID: 29329257 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
