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Review
. 2013 Nov 18;14(11):22678-96.
doi: 10.3390/ijms141122678.

Membrane signaling induced by high doses of ionizing radiation in the endothelial compartment. Relevance in radiation toxicity

Isabelle Corre  1 , Maëva Guillonneau, François Paris
Affiliations
Review

Membrane signaling induced by high doses of ionizing radiation in the endothelial compartment. Relevance in radiation toxicity

Isabelle Corre et al. Int J Mol Sci. .

Abstract

Tumor areas can now be very precisely delimited thanks to technical progress in imaging and ballistics. This has also led to the development of novel radiotherapy protocols, delivering higher doses of ionizing radiation directly to cancer cells. Despite this, radiation toxicity in healthy tissue remains a major issue, particularly with dose-escalation in these new protocols. Acute and late tissue damage following irradiation have both been linked to the endothelium irrigating normal tissues. The molecular mechanisms involved in the endothelial response to high doses of radiation are associated with signaling from the plasma membrane, mainly via the acid sphingomyelinase/ceramide pathway. This review describes this signaling pathway and discusses the relevance of targeting endothelial signaling to protect healthy tissues from the deleterious effects of high doses of radiation.

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Figures

Figure 1
Figure 1
Early and late effects of ionizing radiations on endothelial cells. Relevance in tissue radiation toxicity.
Figure 2
Figure 2
Targeting the ASMase pathway in the endothelium. See text for details.
Figure 3
Figure 3
Diagram of the plasma membrane signaling pathways induced by ionizing radiation in endothelial cells. See text for details.
See this image and copyright information in PMC

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