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Comment
. 2014 Jan;15(1):16-8.
doi: 10.4161/cbt.27149. Epub 2013 Nov 19.

The androgen receptor transcriptional program in castration-resistant prostate cancer: cell lines vs. tissue samples

Jeffrey E Roth  1 , Cody J Peer  1 , Douglas K Price  1 , William D Figg  1
Affiliations
Comment

The androgen receptor transcriptional program in castration-resistant prostate cancer: cell lines vs. tissue samples

Jeffrey E Roth et al. Cancer Biol Ther. 2014 Jan.

Abstract

The androgen receptor (AR) is central to the initiation and progression of prostate cancer, even after castration. Its transcriptional activity has previously been studied in cell lines. A group at the University of Cambridge recently outlined the AR transcriptional program in tissue samples, with an emphasis on castration-resistant tumors. AR binding sites, gene-expression changes (in xenografts), and potential transcription factor interactions were notably different from those observed in cultured cells. These discrepancies suggest a distinct signaling network for the AR in vivo and serve as a reminder that results from in vitro models should be checked against clinical realities.

Keywords: androgen receptor; binding site; castration-resistant prostate cancer; transcription factor; transcriptional program.

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References

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