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. 1985 Apr;4(2):81-3.
doi: 10.1007/BF00269212.

Polyamines and crown gall tumor growth

J M Kulpa  1 , A G Galsky, P Lipetz, R Stephens
Affiliations

Polyamines and crown gall tumor growth

J M Kulpa et al. Plant Cell Rep. 1985 Apr.

Abstract

The effect of the polyamine spermidine on the growth of crown gall tumors was determined using the potato disc bioassay. Addition of lmM spermidine resulted in a 30-50% increase in tumor growth. The spermidine effect was found to be biphasic, with lmM being optimal. Closely related polyamines including spermine, as well as other nitrogen containing compounds such as arginine and alanine, failed to promote tumor growth or inhibited the growth of these tumors. Endogenous levels of spermidine in crown gall tumor tissue were consistently greater than those of corresponding normal potato tissue. Rapidly dividing normal potato tissue derived from buds also contained elevated spermidine levels.

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References

    1. Planta. 1980 Feb;148(1):24-7 - PubMed
    1. Cancer Res. 1973 Nov;33(11):2959-64 - PubMed
    1. Cancer Res. 1975 Jan;35(1):194-8 - PubMed
    1. Biochim Biophys Acta. 1978 Apr 6;473(3-4):241-93 - PubMed
    1. Annu Rev Biochem. 1976;45:285-306 - PubMed