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. 2014 Jan 3;53(1):146-50.
doi: 10.1002/anie.201308141. Epub 2013 Nov 19.

Cascade reactions in multicompartmentalized polymersomes

Ruud J R W Peters  1 , Maïté Marguet, Sébastien Marais, Marco W Fraaije, Jan C M van Hest, Sébastien Lecommandoux
Affiliations

Cascade reactions in multicompartmentalized polymersomes

Ruud J R W Peters et al. Angew Chem Int Ed Engl. .

Abstract

Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.

Keywords: artificial cells; cascade reactions; enzyme catalysis; nanoreactors; polymersomes.

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