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. 1986 Apr;18(1-2):153-4.
doi: 10.1007/BF01988008.

The effects of the anaphylatoxins C3a and C5a on isolated mast cells from rat and man

The effects of the anaphylatoxins C3a and C5a on isolated mast cells from rat and man

H Jürgensen et al. Agents Actions. 1986 Apr.

Abstract

Of the complement peptides comprising anaphylatoxin activity, only C5a caused a very small (less than 1.5%) but statistically significant histamine release from isolated human adenoidal mast cells. C3a and the respective des-Arg-derivatives were found to be ineffective. In rat peritoneal mast cells, neither peptide caused histamine release.

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