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. 1986 Apr;18(1-2):153-4.
doi: 10.1007/BF01988008.

The effects of the anaphylatoxins C3a and C5a on isolated mast cells from rat and man

H Jürgensen, H Behrendt, B Damerau, W Schmutzler

The effects of the anaphylatoxins C3a and C5a on isolated mast cells from rat and man

H Jürgensen et al. Agents Actions. 1986 Apr.

Abstract

Of the complement peptides comprising anaphylatoxin activity, only C5a caused a very small (less than 1.5%) but statistically significant histamine release from isolated human adenoidal mast cells. C3a and the respective des-Arg-derivatives were found to be ineffective. In rat peritoneal mast cells, neither peptide caused histamine release.

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