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. 1986 Apr;18(1-2):239-41.
doi: 10.1007/BF01988030.

Bronchial hyper-reactivity in atopic patients during H2-receptor blocker treatment

J Hofman, Z Siergiejko, J Bortkiewicz, R Rutkowski, S Chyrek-Borowska

Bronchial hyper-reactivity in atopic patients during H2-receptor blocker treatment

J Hofman et al. Agents Actions. 1986 Apr.

Abstract

Bronchial reactivity after Cimetidine treatment was evaluated by the histamine provocation test in 24 patients with atopic bronchial asthma and 10 patients with peptic ulcer. Anti-IgE induced histamine release from isolated basophils was also investigated. After blockade of H2 receptors, an increase of bronchial reactivity and an exacerbation of clinical symptoms were observed in 4 asthmatic patients [17%]. A moderate increase in bronchial reactivity without exacerbation of asthma symptoms was observed in 16 other patients [66%]. In some of the patients treated with Cimetidine an enhancement of IgE-induced histamine release from isolated basophils was observed.

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References

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