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Review
. 2014 Feb;48(1):4-14.
doi: 10.3109/21681805.2013.861508. Epub 2013 Nov 21.

Diethylstilboestrol for the treatment of prostate cancer: past, present and future

Rafal Turo  1 , Michal Smolski, Rachel Esler, Magda L Kujawa, Stephen J Bromage, Neil Oakley, Adebanji Adeyoju, Stephen C W Brown, Richard Brough, Andrew Sinclair, Gerald N Collins
Affiliations
Review

Diethylstilboestrol for the treatment of prostate cancer: past, present and future

Rafal Turo et al. Scand J Urol. 2014 Feb.

Abstract

The aim of this review was to discuss the most recent data from current trials of diethylstilboestrol (DES) to identify its present role in advanced prostate cancer treatment as new hormonal therapies emerge. The most relevant clinical studies using DES in castration-refractory prostate cancer (CRPC) were identified from the literature. The safety, efficacy, outcomes and mechanisms of action are summarized. In the age of chemotherapy this review highlights the efficacy of oestrogen therapy in CRPC. The optimal point in the therapeutic pathway at which DES should be prescribed remains to be established.

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