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. 2014 Apr;41(2):95-7.
doi: 10.1111/iji.12096. Epub 2013 Nov 21.

HLA-B50 polymorphism in the Saudi population

D Jawdat  1 , B Al-Hamad, M Al-Jumah, A Hajeer
Affiliations

HLA-B50 polymorphism in the Saudi population

D Jawdat et al. Int J Immunogenet. 2014 Apr.

Abstract

The HLA-B50 serologic family is very frequent in people of Arabic origin. In Saudi Arabia, HLA-B50 is the most frequent HLA-B allele. The aim of this study was to investigate the distribution of HLA-B50 alleles in healthy Saudi individuals. A total of 162 healthy Saudi individuals were selected based on low-resolution HLA typing. DNA samples were typed by sequence-based typing method for exons 2, 3 and 4 of the HLA-B locus (Genome Diagnostics B.V.). The HLA-B*50 alleles were analysed using SBT engine software. HLA-B*50:01:01 was found in 161 of 162 individuals (99.4%), while HLA-B*50:09 was found in one individual (0.6%). HLA-B*50:01:01 is the most common HLA-B50 allele in Saudi Arabia.

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