Role of alveolar macrophage- and lung T cell-derived mediators in pulmonary sarcoidosis

Abstract

The process of granuloma formation in the lung is mediated by an intimate interaction between macrophages and T cells, and this interaction provides the appropriate environment for granuloma formation and the development of fibrosis. Much of this process of granuloma formation and fibrosis appears to be triggered by the release of immune mediators by alveolar macrophages and lung T cells.