Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Nov 19;5(11):2796-802.
doi: 10.3390/v5112796.

Large scale genome analysis shows that the epitopes for broadly cross-reactive antibodies are predominant in the pandemic 2009 influenza virus A H1N1 strain

Edgar E Lara-Ramírez  1 , Aldo Segura-Cabrera, Ma Isabel Salazar, Mario A Rodríguez-Pérez, Xianwu Guo
Affiliations

Large scale genome analysis shows that the epitopes for broadly cross-reactive antibodies are predominant in the pandemic 2009 influenza virus A H1N1 strain

Edgar E Lara-Ramírez et al. Viruses. .

Abstract

The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal influenza viruses. It has changed the pre-existing immunity of the human population to succeeding infections. In the present study, a total of 14,210 distinct sequences downloaded from National Center for Biotechnology Information (NCBI) database were used for the analysis. The epitope compositions in A (H1N1)pdm09, classic seasonal strains, swine strains as well as highly virulent avian strain H5N1, identified with the aid of the Immune Epitope DataBase (IEDB), were compared at genomic level. The result showed that A (H1N1) pdm09 contains the 90% of B-cell epitopes for broadly cross-reactive antibodies (EBCA), which is in consonance with the recent reports on the experimental identification of new epitopes or antibodies for this virus and the binding tests with influenza virus protein HA of different subtypes. Our analysis supports that high proportional EBCA depends on the epitope pattern of A (H1N1)pdm09 virus. This study may be helpful for better understanding of A (H1N1)pdm09 and the production of new influenza vaccines.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Centers for Disease Control and Prevention. National and Regional Level Outpatient Illness and Viral Surveillance. [(accessed on 10 November 2012)]. Available online: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.
    1. Wrammert J., Koutsonanos D., Li G.M., Edupuganti S., Sui J., Morrissey M., McCausland M., Skountzou I., Hornig M., Lipkin W.I., et al. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J. Exp. Med. 2011;208:181–193. doi: 10.1084/jem.20101352. - DOI - PMC - PubMed
    1. Qiu C., Huang Y., Wang Q., Tian D., Zhang W., Hu Y., Yuan Z., Zhang X., Xu J. Boosting heterosubtypic neutralization antibodies in recipients of 2009 pandemic H1N1 influenza vaccine. Clin. Infect. Dis. 2011;54:17–24. - PMC - PubMed
    1. Li G.M., Chiu C., Wrammert J., McCausland M., Andrews S.F., Zheng N.Y., Lee J.H., Huang M., Qu X., Edupuganti S., et al. Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc. Natl. Acad. Sci. USA. 2012;109:9047–9052. doi: 10.1073/pnas.1118979109. - DOI - PMC - PubMed
    1. Chen Y., Qin K., Wu W.L., Li G., Zhang J., Du H., Ng M.H., Shih J.W., Peiris J.S., Guan Y., et al. Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes. J. Infect. Dis. 2009;199:49–58. doi: 10.1086/594374. - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources