Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Dec;4(12):2171-85.
doi: 10.18632/oncotarget.1426.

Chemokines in tumor progression and metastasis

Purvaba J Sarvaiya  1 , Donna Guo, Ilya Ulasov, Patrik Gabikian, Maciej S Lesniak
Affiliations
Review

Chemokines in tumor progression and metastasis

Purvaba J Sarvaiya et al. Oncotarget. 2013 Dec.

Abstract

Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, melanoma, lung cancer, gastric cancer, acute lymphoblastic leukemia, colon cancer, non-small lung cancer, non-hodgkin's lymphoma, etc. The expression of chemokines and their receptors is altered in many malignancies and leads to aberrant chemokine receptor signaling. This review focuses on the role of chemokines in key processes that facilitate tumor progression including proliferation, senescence, angiogenesis, epithelial mesenchymal transition, immune evasion and metastasis.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest

References

    1. Raman D, Sobolik-Delmaire T, Richmond A. Chemokines in health and disease. Exp. Cell Res. 2011;317(5):575–589. - PMC - PubMed
    1. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity. 2000;12(2):121–127. - PubMed
    1. Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 2000;52(1):145–176. - PubMed
    1. Schall TJ, Proudfoot AE. Overcoming hurdles in developing successful drugs targeting chemokine receptors. Nat Rev Immunol. 2011;11(5):355–363. - PubMed
    1. Olson TS, Ley K. Chemokines and chemokine receptors in leukocyte trafficking. Am. J. Physiol. 2002;283(1):R7–28. - PubMed

Publication types