Understanding and treatment of chronic pancreatitis
- PMID: 24259951
- PMCID: PMC3831202
- DOI: 10.3748/wjg.v19.i42.7219
Understanding and treatment of chronic pancreatitis
Abstract
Chronic pancreatitis is characterized by an inflammatory process of the pancreas, which is replaced by fibrosis and progressive destruction. The three major clinical features of chronic pancreatitis are pain, maldigestion, and diabetes. Chronic pancreatitis has a profound impact on social life and employment patterns. In the current issue, different topics highlight experimental models of chronic pancreatitis and bridge findings from recent research to bedside. Although the disease is still difficult to treat the current papers represent useful guidelines on how to approach chronic pancreatitis in the clinical settings with the major aim to improve the patient's suffering and quality of life.
Keywords: Chronic pancreatitis; Diabetes; Pathogenesis; Treatment.
Similar articles
-
A fire inside: current concepts in chronic pancreatitis.Intern Med J. 2008 Jul;38(7):592-8. doi: 10.1111/j.1445-5994.2008.01715.x. Intern Med J. 2008. PMID: 18715303 Review.
-
Chronic pancreatitis.Nat Rev Dis Primers. 2017 Sep 7;3:17060. doi: 10.1038/nrdp.2017.60. Nat Rev Dis Primers. 2017. PMID: 28880010 Review.
-
Pathophysiology of chronic pancreatitis.World J Gastroenterol. 2013 Nov 14;19(42):7231-40. doi: 10.3748/wjg.v19.i42.7231. World J Gastroenterol. 2013. PMID: 24259953 Free PMC article. Review.
-
[Pathogenesis and treatment of pain in chronic pancreatitis].Orv Hetil. 2007 Mar 4;148(9):397-403. doi: 10.1556/OH.2007.27979. Orv Hetil. 2007. PMID: 17344167 Review. Hungarian.
-
Chronic Pancreatitis: Epidemiology, Diagnosis, and Management Updates.Drugs. 2020 Aug;80(12):1155-1168. doi: 10.1007/s40265-020-01360-6. Drugs. 2020. PMID: 32647920 Review.
Cited by
-
Arecae pericarpium water extract alleviates chronic pancreatitis by deactivating pancreatic stellate cells.Front Pharmacol. 2022 Aug 29;13:941955. doi: 10.3389/fphar.2022.941955. eCollection 2022. Front Pharmacol. 2022. PMID: 36105227 Free PMC article.
-
HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis.Hum Cell. 2020 Oct;33(4):1006-1016. doi: 10.1007/s13577-020-00387-x. Epub 2020 Jun 11. Hum Cell. 2020. PMID: 32524326 Free PMC article.
-
Influences of exocrine pancreatic insufficiency on nutrient digestibility, growth parameters as well as anatomical and histological morphology of the intestine in a juvenile pig model.Front Med (Lausanne). 2022 Sep 9;9:973589. doi: 10.3389/fmed.2022.973589. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36160141 Free PMC article.
-
Long term follow-up of a simplified and less burdened pancreatic duct ligation model of exocrine pancreatic insufficiency in Goettingen Minipigs.BMC Gastroenterol. 2020 Nov 30;20(1):403. doi: 10.1186/s12876-020-01541-3. BMC Gastroenterol. 2020. PMID: 33256637 Free PMC article.
-
Gut microbiome as a response marker for pancreatic enzyme replacement therapy in a porcine model of exocrine pancreas insufficiency.Microb Cell Fact. 2020 Dec 3;19(1):221. doi: 10.1186/s12934-020-01482-2. Microb Cell Fact. 2020. PMID: 33272255 Free PMC article.
References
-
- Yadav D, Timmons L, Benson JT, Dierkhising RA, Chari ST. Incidence, prevalence, and survival of chronic pancreatitis: a population-based study. Am J Gastroenterol. 2011;106:2192–2199. - PubMed
-
- Gardner TB, Kennedy AT, Gelrud A, Banks PA, Vege SS, Gordon SR, Lacy BE. Chronic pancreatitis and its effect on employment and health care experience: results of a prospective American multicenter study. Pancreas. 2010;39:498–501. - PubMed
-
- Lowenfels AB, Sullivan T, Fiorianti J, Maisonneuve P. The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep. 2005;7:90–95. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources