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. 2013 Nov 18;8(11):e80711.
doi: 10.1371/journal.pone.0080711. eCollection 2013.

No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire

Carola Bindt  1 , Nan Guo, Marguerite Te Bonle, John Appiah-Poku, Rebecca Hinz, Dana Barthel, Stefanie Schoppen, Torsten Feldt, Claus Barkmann, Mathurin Koffi, Wibke Loag, Samuel Blay Nguah, Kirsten A Eberhardt, Harry Tagbor, Eliezer N'goran, Stephan Ehrhardt; International CDS Study Group
Collaborators, Affiliations

No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire

Carola Bindt et al. PLoS One. .

Abstract

Background: Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms and birth outcomes in a low-obstetric risk sample of mother/child dyads in Ghana and Côte d'Ivoire.

Methods: In 2010-2011, a prospective cohort of 1030 women in their third trimester in Ghana and Côte d'Ivoire was enrolled. Depression and anxiety were assessed in the third trimester using the Patient Health Questionnaire depression module and the 7-item Generalized Anxiety Disorder scale. 719 mother/child dyads were included in the analysis. We constructed multivariate regression models to estimate the association between CMD and low birth weight (LBW), and preterm birth (PTB) to control for potential confounders.

Results: The prevalence of depression and anxiety symptoms were 28.9% and 14.2% respectively. The mean birth weight was 3172.1g (SD 440.6) and the prevalence of LBW was 1.7%. The mean gestational age was 39.6 weeks and the proportion of PTB was 4%. Multivariate linear regression revealed no significant association between maternal depression (B=52.2, 95% CI -18.2 122.6, p=0.15) or anxiety (B=17.1, 95% CI -74.6 108.7, p=0.72) and birth weight. Yet, low socio-economic status, female sex of the child, and younger maternal age were associated with lower birth weight. Multivariate logistic regression suggested no significant association between maternal depression (OR: 2.1, 95% CI 0.8 5.6, p=0.15) or anxiety (OR: 1.8, 95% CI 0.6 5.5, p=0.29) with PTB.

Conclusions: Our data suggests that depression and/or anxiety in the 3(rd) trimester of pregnancy are not independent predictors of adverse birth outcomes in low obstetric risk women. The role of pregnancy complications as confounders or effect modifiers in studies of maternal CMD and their impact on birth outcomes should be investigated.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Study flow.
See this image and copyright information in PMC

References

    1. Ashdown-Lambert JR (2005) A review of low birth weight: predictors, precursors and morbidity outcomes. J R Soc Promot Health 125: 76-83. doi:10.1177/146642400512500211. PubMed: 15819182. - DOI - PubMed
    1. Leitner Y, Fattal-Valevski A, Geva R, Eshel R, Toledano-Alhadef H et al. (2007) Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective study. J Child Neurol 22: 580-587. doi:10.1177/0883073807302605. PubMed: 17690065. - DOI - PubMed
    1. Saigal S, Doyle LW (2008) An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 371: 261-269. doi:10.1016/S0140-6736(08)60136-1. PubMed: 18207020. - DOI - PubMed
    1. O'Keane V, Marsh MS (2007) Depression during pregnancy. BMJ 334: 1003-1005. doi:10.1136/bmj.39189.662581.55. PubMed: 17494021. - DOI - PMC - PubMed
    1. Ross LE, McLean LM (2006) Anxiety disorders during pregnancy and the postpartum period: A systematic review. J Clin Psychiatry 67: 1285-1298. doi:10.4088/JCP.v67n0818. PubMed: 16965210. - DOI - PubMed

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