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. 2014 Jan;102(1):60-9.
doi: 10.5935/abc.20130226. Epub 2013 Nov 22.

Blood pressure in adolescence, adipokines and inflammation in young adults. The rio de janeiro study

[Article in English, Portuguese]
Erika Maria Gonçalves Campana  1 , Andréa Araujo Brandão  1 , Roberto Pozzan  1 , Maria Eliane Campos Magalhães  1 , Flávia Lopes Fonseca  1 , Oswaldo Luiz Pizzi  1 , Elizabete Viana de Freitas  1 , Ayrton Pires Brandão  1
Affiliations

Blood pressure in adolescence, adipokines and inflammation in young adults. The rio de janeiro study

[Article in English, Portuguese]
Erika Maria Gonçalves Campana et al. Arq Bras Cardiol. 2014 Jan.

Abstract

Background: The impact of blood pressure (BP) during adolescence on other cardiovascular risk factors in young adults is important for the primary prevention.

Objective: To evaluate BP, anthropometric indexes, metabolic and inflammatory profiles in young individuals stratified by their BP behavior recorded for 18 years.

Methods: A total of 116 individuals, of whom 63 were males, from the Rio de Janeiro study (follow-up of 17.76 ± 1.63 years), were assessed at two moments: A1 (12.40 ± 1.49 years) and A2 (30.09 ± 2.01 years). The 116 individuals were divided into two groups: GN (n = 71), of participants with normal BP at A1; and GH (n = 45), of those with abnormal BP at A1. BP, weight, height and body mass index (BMI) were measured at A1 and A2. At A2, abdominal circumference (AC) and laboratory, metabolic and inflammatory variables were included.

Results: 1) No difference was observed between the groups as regards age and gender; 2) At A2, GH showed higher mean weight, BMI, BP, insulin, HOMA-IR (p < 0.001), leptin (p < 0.02), apolipoprotein B100 and A1 (p < 0.02), apolipoprotein B100 / apolipoprotein A1 ratio (p < 0.010); and higher prevalences of overweight/obesity (p < 0.001), of increased AC (p < 0.001) and of hypertension (p < 0.02); 3) No difference was observed between the groups as regards the inflammatory variables; 4) There was a positive correlation of BP at A1 with BP, BMI, insulin, leptin and HOMA-IR at A2 (p < 0.05).

Conclusion: BP in adolescence was associated with higher values of BP, and anthropometric and metabolic variables in young adulthood, but not with inflammatory variables.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
The Rio de Janeiro study design-. Second Stage. WPV: pulse wave velocity; ECG: electrocardiogram; OGTT: oral glucose tolerance test.
Figure 2
Figure 2
Composition of the population sample of the present study
Figure 3
Figure 3
Prevalence of hypertension, overweight/obesity, increased abdominal circumference, and metabolic syndrome at A2 in the groups of normal (GN) and hypertensive (GH) individuals. HBP: high blood pressure; OW/O: overweight/obesity; increased AC: increased abdominal circumference; MS: metabolic syndrome.
See this image and copyright information in PMC

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