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Clinical Trial
. 2013 Dec;62(12):3976-86.
doi: 10.2337/db13-1093.

Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions

David M Nathan  1 , Margaret Bayless, Patricia Cleary, Saul Genuth, Rose Gubitosi-Klug, John M Lachin, Gayle Lorenzi, Bernard Zinman; DCCT/EDIC Research Group
Collaborators, Affiliations
Clinical Trial

Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions

David M Nathan et al. Diabetes. 2013 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Study time line of the DCCT/EDIC Study. RFA, research funding announcement.
FIG. 2.
FIG. 2.
Median HbA1c from DCCT through EDIC year 19. HbA1c was measured quarterly in CONV (dashed line) and INT (solid line) during DCCT and annually during EDIC.
FIG. 3.
FIG. 3.
Intensive treatment reduction (%) in cumulative incidence of complications during DCCT, during EDIC (further progression, adjusting for level of complications at DCCT end), and during DCCT/EDIC combined. CVD events include nonfatal myocardial infarction or stroke or fatal CVD events; Macroalb, macroalbuminuria >300 mg/24 h; Microalb, microalbuminuria ≥40 mg/24 h; Neuropathy, clinical neuropathy consisting of the presence of signs/symptoms consistent with peripheral neuropathy and presence of either abnormal electrophysiologic findings of peripheral neuropathy or abnormal autonomic function testing (see ref. 17); severe eye, defined as proliferative diabetic retinopathy, clinically significant macular edema, laser surgery, ocular surgery (including cataract extraction, vitrectomy, glaucoma-related, other cornea–related, posterior capsulotomy, and enucleation), and blindness; Prim, primary prevention cohort; Reduced GFR, reduced glomerular filtration rate <60 mL/min/1.73 m2; Scnd, secondary intervention cohort.
FIG. 4.
FIG. 4.
A: Relationship of current updated mean HbA1c levels with three-step progression of retinopathy. B: Relationship of current HbA1c levels measured every 3 months during DCCT with occurrence of severe hypoglycemia, defined as episodes of hypoglycemia requiring assistance for treatment. PYR, patient-years.
See this image and copyright information in PMC

References

    1. The DCCT Research Group The Diabetes Control and Complications Trial (DCCT). Design and methodologic considerations for the feasibility phase. Diabetes 1986;35:530–545 - PubMed
    1. Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group Epidemiology of Diabetes Interventions and Complications (EDIC). Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort. Diabetes Care 1999;22:99–111 - PMC - PubMed
    1. The Diabetes Control and Complications Trial Research Group The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–986 - PubMed
    1. Nathan DM. Long-term complications of diabetes mellitus. N Engl J Med 1993;328:1676–1685 - PubMed
    1. Deckert T, Poulsen JE, Larsen M. Prognosis of diabetics with diabetes onset before the age of thirty-one. I. Survival, causes of death, and complications. Diabetologia 1978;14:363–370 - PubMed

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