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Comment
. 2013 Dec;62(12):3987-9.
doi: 10.2337/db13-1278.

Soaping up type 2 diabetes with bile acids?: the link between glucose and bile acid metabolism in humans tightens: quality matters!

Bart Staels  1 , Janne Prawitt
Affiliations
Comment

Soaping up type 2 diabetes with bile acids?: the link between glucose and bile acid metabolism in humans tightens: quality matters!

Bart Staels et al. Diabetes. 2013 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Schematic overview of bile acid synthesis and its regulation. Changes in insulin resistance and/or type 2 diabetes are indicated in orange. 12αOH, 12α-hydroxylated BA.
See this image and copyright information in PMC

Comment on

References

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    1. Prawitt J, Caron S, Staels B. Bile acid metabolism and the pathogenesis of type 2 diabetes. Curr Diab Rep 2011;11:160–166 - PMC - PubMed
    1. Haeusler RA, Astiarraga B, Camastra S, Accili D, Ferrannini E. Human insulin resistance is associated with increased plasma levels of 12α hydroxylated bile acids. Diabetes 2013;62:4184–4191 - PMC - PubMed
    1. Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab 2012;15:65–74 - PMC - PubMed
    1. Duran-Sandoval D, Mautino G, Martin G, et al. Glucose regulates the expression of the farnesoid X receptor in liver. Diabetes 2004;53:890–898 - PubMed

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