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Comment
. 2013 Dec;62(12):3996-8.
doi: 10.2337/db13-1325.

New insights into metabolic regulation via bifurcated function of estrogen receptor α

Tsutomu Wada  1 , Hiroshi Tsuneki, Toshiyasu Sasaoka
Affiliations
Comment

New insights into metabolic regulation via bifurcated function of estrogen receptor α

Tsutomu Wada et al. Diabetes. 2013 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Bifurcation of genomic functions of estrogen at AF1 and AF2 in ERα. ERα is composed of six functional domains: N-terminal (A/B), DNA-binding (C), hinge region (D), hormone-binding (E), COOH-terminal (F). Estrogen binds to ligand-binding domain (LBD) of ERα and promotes its translocation to the nucleus. Subsequently, the ERα binds to estrogen response elements (ERE) on the promoter region of specific genes via DNA-binding domain (DBD). Both AF1 and AF2 in ERα interact with transcriptional coactivators and/or corepressors and coordinately regulate transcription of genes. Importantly, the metabolic effects of estrogen are mediated through AF2. In contrast, AF1 is responsible for the estrogen-mediated proliferation of endometrial and breast cancer cells.
See this image and copyright information in PMC

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