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Comment
. 2013 Dec;62(12):4009-11.
doi: 10.2337/db13-1445.

Islet autoantibody testing: an end to the trials and tribulations?

Polly J Bingley  1 , Alistair J K Williams
Affiliations
Comment

Islet autoantibody testing: an end to the trials and tribulations?

Polly J Bingley et al. Diabetes. 2013 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Discrimination of disease-relevant autoantibodies from those conferring low risk of T1D. Autoantibody characteristics associated with high risk of disease include high titer and affinity, specificity for T1D-associated epitopes, as well as positivity for multiple islet autoantibodies. Autoantibody assay signals associated with low risk of T1D may derive from assay nonspecific binding or by detection of autoantibodies not relevant to β-cell destruction. The importance of each antibody characteristic will vary according to antibody and assay type, with a balance to be struck between improving specificity and loss of sensitivity. The reported ECL assays for IAA and GADA appear to detect predominantly high-affinity antibodies that are strongly associated with disease and to achieve higher specificity than established RIAs without loss of sensitivity.
See this image and copyright information in PMC

Comment on

References

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