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Comment
. 2013 Nov 22;342(6161):940-1.
doi: 10.1126/science.1247514.

Molecular biology. Chromosome capture brings it all together

Nancy Kleckner  1 , Denise Zickler, Guillaume Witz
Affiliations
Comment

Molecular biology. Chromosome capture brings it all together

Nancy Kleckner et al. Science. .

Abstract

A simple, robust model explains higher-order organization of mammalian chromosomes.

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Figures

Figure 1
Figure 1. Meiotic and mitotic chromosomes
(A) Meiotic homologs of Chironomus, each comprising sister linear loop arrays (14). (B, C, D) Mitotic metaphase chromosomes in a human cell line. (B, C) Radially central chromosome “barber pole” appearance due to staining for DNA (blue) and associated proteins (red and green (4). (D) Radial loops of chromatin fibers (15). (E) A model of the two stages of chromosome assembly from Naumova et al. (1).
See this image and copyright information in PMC

Comment on

  • Organization of the mitotic chromosome.
    Naumova N, Imakaev M, Fudenberg G, Zhan Y, Lajoie BR, Mirny LA, Dekker J. Naumova N, et al. Science. 2013 Nov 22;342(6161):948-53. doi: 10.1126/science.1236083. Epub 2013 Nov 7. Science. 2013. PMID: 24200812 Free PMC article.

References

    1. Naumova N, et al. Science. 2013;XX:XXX.
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    1. Maeshima K, Laemmli UK. Dev Cell. 2003;4:467. - PubMed
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