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. 2013 Nov 24;3(1):45.
doi: 10.1186/2045-3701-3-45.

The KCTD family of proteins: structure, function, disease relevance

Zhepeng Liu #  1 , Yaqian Xiang #  2 , Guihong Sun  1
Affiliations

The KCTD family of proteins: structure, function, disease relevance

Zhepeng Liu et al. Cell Biosci. .

Abstract

The family of potassium channel tetramerizationdomain (KCTD) proteins consists of 26 members with mostly unknown functions. The name of the protein family is due to the sequence similarity between the conserved N-terminal region of KCTD proteins and the tetramerization domain in some voltage-gated potassium channels. Dozens of publications suggest that KCTD proteins have roles in various biological processes and diseases. In this review, we summarize the character of Bric-a-brack,Tram-track, Broad complex(BTB) of KCTD proteins, their roles in the ubiquitination pathway, and the roles of KCTD mutants in diseases. Furthermore, we review potential downstream signaling pathways and discuss future studies that should be performed.

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Figures

Figure 1
Figure 1
A paralogues tree of the KCTD family proteins as cullin ligase adaptor and their substrate. Left: A paralogues tree built using entire amino acid sequences of the KCTD family proteins; Right: the family of KCTD proteins corresponding to cullin and their substrate.
See this image and copyright information in PMC

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