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Comment
. 2013 Dec;45(12):1413-4.
doi: 10.1038/ng.2832.

Recurrent H3.3 alterations in childhood tumors

Anders M Lindroth  1 , Christoph Plass
Affiliations
Comment

Recurrent H3.3 alterations in childhood tumors

Anders M Lindroth et al. Nat Genet. 2013 Dec.

Abstract

Comprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers.

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Comment on

  • Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
    Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, Wedge DC, Cooke SL, Gundem G, Davies H, Nik-Zainal S, Martin S, McLaren S, Goodie V, Robinson B, Butler A, Teague JW, Halai D, Khatri B, Myklebost O, Baumhoer D, Jundt G, Hamoudi R, Tirabosco R, Amary MF, Futreal PA, Stratton MR, Campbell PJ, Flanagan AM. Behjati S, et al. Nat Genet. 2013 Dec;45(12):1479-82. doi: 10.1038/ng.2814. Epub 2013 Oct 27. Nat Genet. 2013. PMID: 24162739 Free PMC article.

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