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. 1985 Nov;2(6):253-61.
doi: 10.1023/A:1016381215385.

Leukotriene biosynthesis inhibitors

J R Cashman  1
Affiliations

Leukotriene biosynthesis inhibitors

J R Cashman. Pharm Res. 1985 Nov.

Abstract

This review describes the design and current development of leukotriene biosynthesis inhibitors as potential antiinflammatory agents. Knowledge of the enzymatic mechanism of 5-lipoxygenase led to specific inhibitors of this enzyme which catalyzes a key step in the leukotriene pathway. Competitive inhibitors include iron chelators, redox agents and alternate substrates. Further, the potential of product inhibitors and mechanism based inactivators of 5-lipoxygenase is discussed.

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