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. 2014 Apr;121(4):379-83.
doi: 10.1007/s00702-013-1120-z. Epub 2013 Nov 23.

Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

Jasmin Bartl  1 , Thomas Müller, Edna Grünblatt, Manfred Gerlach, Peter Riederer
Affiliations

Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

Jasmin Bartl et al. J Neural Transm (Vienna). 2014 Apr.

Abstract

Patients with Parkinson's disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.

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