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Comment
. 2013 Dec 3;110(49):19662-3.
doi: 10.1073/pnas.1320604110. Epub 2013 Nov 22.

Structure of Escherichia coli RNA polymerase holoenzyme at last

Lucia B Rothman-Denes  1
Affiliations
Comment

Structure of Escherichia coli RNA polymerase holoenzyme at last

Lucia B Rothman-Denes. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic of EcoRNAPσ70. (A) σ1.1 is present in the active site channel but displaced during open complex formation allowing downstream DNA binding (B). (C) EcoRNAPσ70 is complexed with Gp2, which interacts with the β′ jaw and σ1.1, blocking downstream DNA binding and open complex formation. (Adapted from ref. .) (D) Schematic representation of the yeast RNAPII 32-protein preinitiation complex. RNAPII is depicted in gray at the bottom. The general transcription factors are depicted at the top with the C terminus of Ssl2, a component of TFIIH, extending over the cleft to interact with polII and preventing the DNA from entering the cleft. (Adapted from ref. .)
See this image and copyright information in PMC

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References

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