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Randomized Controlled Trial
. 2014 Winter;26(1):57-63.
doi: 10.1176/appi.neuropsych.12120381.

Neuropsychological outcomes after psychosocial intervention for depression in Parkinson's disease

Roseanne D Dobkin, Alexander I Tröster, Jade Tiu Rubino, Lesley A Allen, Michael A Gara, Margery H Mark, Matthew Menza
Randomized Controlled Trial

Neuropsychological outcomes after psychosocial intervention for depression in Parkinson's disease

Roseanne D Dobkin et al. J Neuropsychiatry Clin Neurosci. 2014 Winter.

Abstract

The authors describe neuropsychological outcomes in people with Parkinson's disease (PD) after their participation in an NIH-sponsored, randomized, controlled trial of cognitive-behavioral treatment for depression. Improvements in mood were associated with modest gains in verbal memory and executive functioning over the 10-week treatment period and accounted for greater variance in neuropsychological outcomes at the end of treatment than other known correlates of cognitive functioning in PD, such as disease severity, age, and education. Baseline working memory and executive skills were also associated with depression improvement over time.

Trial registration: ClinicalTrials.gov NCT00464464.

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References

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