Prostate cancer: Intermediate efficacy end points to assess modern therapies
- PMID: 24276080
- PMCID: PMC6594368
- DOI: 10.1038/nrurol.2013.269
Prostate cancer: Intermediate efficacy end points to assess modern therapies
Abstract
A retrospective, single institution study of 450 men with biochemical recurrence after radical prostatectomy included 140 men with androgen deprivation therapy deferred until metastatic disease onset. Metastasis-free survival was an independent predictor of overall survival. This research highlights the need to develop appropriate intermediate end points to expedite prostate cancer treatment.
Conflict of interest statement
Competing interests
The authors declare no competing interests.
Comment on
-
Metastasis-free survival is associated with overall survival in men with PSA-recurrent prostate cancer treated with deferred androgen deprivation therapy.Ann Oncol. 2013 Nov;24(11):2881-6. doi: 10.1093/annonc/mdt335. Epub 2013 Aug 14. Ann Oncol. 2013. PMID: 23946329 Free PMC article. Clinical Trial.
References
-
- Sonpavde G & Palapattu GS Neoadjuvant therapy preceding prostatectomy for prostate cancer: rationale and current trials. Expert Rev. Anticancer Ther 10, 439–450 (2010). - PubMed
-
- Eastham JA, Kelly WK, Grossfeld GD, Small EJ & Cancer & Leukemia Group B. Cancer and Leukemia Group B (CALGB) 90203: a randomized phase 3 study of radical prostatectomy alone versus estramustine and docetaxel before radical prostatectomy for patients with high-risk localized disease. Urology 62 (Suppl. 1), 55–62 (2003). - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
