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. 2014 Jan 14;12(2):255-60.
doi: 10.1039/c3ob41539b.

Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

James McNulty  1 , Ramesh Vemula, Claudia Bordón, Robert Yolken, Lorraine Jones-Brando
Affiliations

Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

James McNulty et al. Org Biomol Chem. .

Abstract

A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.

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