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Meta-Analysis
. 2013 Nov 22;8(11):e82133.
doi: 10.1371/journal.pone.0082133. eCollection 2013.

FTO gene variant and risk of overweight and obesity among children and adolescents: a systematic review and meta-analysis

Chibo Liu  1 , Sihua Mou, Yangqun Cai
Affiliations
Meta-Analysis

FTO gene variant and risk of overweight and obesity among children and adolescents: a systematic review and meta-analysis

Chibo Liu et al. PLoS One. .

Abstract

Objective: The fat mass and obesity associated gene (FTO) polymorphisms have been implicated in the susceptibility of overweight/obesity in children and adolescents. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of FTO gene polymorphisms with overweight/obesity risk among children and adolescents.

Methods: PubMed and Embase were used to search for eligible published literatures. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random- or fixed-effect models.

Results: A total of 21 articles containing 23 studies (11208cases and 35015controls) were included in our analysis. The results indicated that variant in FTO gene was significantly associated with increased risk of overweight/obesity in children and adolescents (OR=1.35; 95%CI: 1.27-1.44; P<0.001). The overall pooled ORs for risk obesity and overweight were 1.34 (95%CI: 1.21-1.48) and 1.35 (95%CI: 1.25-1.47), respectively. Subgroup analyses also showed similar trends in most subgroups of adjustment for covariates and unadjustment, different ethnicities (Caucasians, Asians, and Amerindians), and each of three investigated polymorphisms (rs9939609, rs1421085, and rs1558902).

Conclusions: The present meta-analysis suggested a positive association between FTO gene polymorphism and overweight/obesity risk among children and adolescents. Further prospective studies should be recommended to confirm the observed association, and underlying mechanism should be investigated to clarify the association of FTO gene polymorphism with overweight/obesity.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow chart of article selection for meta-analysis.
Figure 2
Figure 2. Forest plot of meta-analysis of the association between rs9939609 (or its proxy) and overweight/obesity among children and adolescents under an additive model.
Figure 3
Figure 3. Begg’s funnel plot for publication bias in an additive model.
See this image and copyright information in PMC

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