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. 2014 Feb;20(2):182-5.
doi: 10.1111/cns.12194. Epub 2013 Nov 27.

Resveratrol attenuates early brain injury after subarachnoid hemorrhage through inhibition of NF-κB-dependent inflammatory/MMP-9 pathway

An-Wen Shao  1 , Hai-Jian Wu, Sheng Chen, Al-baadani Ammar, Jian-Min Zhang, Yuan Hong
Affiliations

Resveratrol attenuates early brain injury after subarachnoid hemorrhage through inhibition of NF-κB-dependent inflammatory/MMP-9 pathway

An-Wen Shao et al. CNS Neurosci Ther. 2014 Feb.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Resveratrol‐treated (30 mg/kg, intraperitoneal) rats exhibited reduced neurological deficits compared with those in the SAH group (B), obviously reduced brain water content (D), and significantly reduced Evans blue dye extravasation in the left hemisphere and right hemisphere (F). There was no difference found in SAH grade or mortality between SAH and RVS groups (A,C,E). Values are expressed as the means ± SD. Statistical significance was analyzed by one‐way analysis of variance (ANOVA) followed by Tukey's test for multiple comparisons. For mortality, Fisher's exact test was used for group comparisons. *P < 0.05 compared with sham group; # P < 0.05 compared with SAH group.
Figure 2
Figure 2
The effect of resveratrol in NF‐κB‐dependent inflammatory/MMP‐9 pathways after SAH induced. The cytoplasm‐to‐nucleus translocation of p65, a subunit of NF‐κB, was induced in the SAH group and inhibited markedly by administration of resveratrol (C–F). The levels of TNF‐a, IL‐1β, and IL‐6 mRNA increased after subarachnoid hemorrhage (SAH), but were suppressed in the resveratrol‐treated group (A,B). Resveratrol increased the expression of MMP‐9 in cortex (G,I) and decreased the level of claudin‐5 and ZO‐1 (H,J,K). Values are expressed as the means ± SD. Statistical significance was analyzed by one‐way analysis of variance (ANOVA) followed by Tukey's test for multiple comparisons. *P < 0.05 compared with sham group; # P < 0.05 compared with SAH group.
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