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. 2013;15(12):1237-42.
doi: 10.1080/10286020.2013.825610. Epub 2013 Nov 27.

Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong

Jian Huang  1 , Xiao-Qing Lu, Jin Lu, Guo-Yu Li, Hang-Yu Wang, Li-Hong Li, Rui-Chao Lin, Jin-Hui Wang
Affiliations

Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong

Jian Huang et al. J Asian Nat Prod Res. 2013.

Abstract

Two new phthalides, chuanxiongdiolides A and B, were isolated from the roots of Ligusticum chuanxiong Hort. Their structures were established by UV, IR, 1D (¹H, ¹³C) and 2D (HSQC, ¹H-¹H COSY, HMBC, NOESY) NMR, and HR-ESI-MS methods, and their absolute configurations were assigned via circular dichroism exciton chirality. The two compounds showed different degrees of inhibitory effects against butyrylcholine esterase.

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