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. 2013 Nov-Dec;4(6):549-67.
doi: 10.4161/gmic.27000. Epub 2013 Nov 6.

What do we know about benefits of H. pylori treatment in childhood?

Mónica S Sierra  1 , Emily V Hastings  1 , Karen J Goodman  1
Affiliations

What do we know about benefits of H. pylori treatment in childhood?

Mónica S Sierra et al. Gut Microbes. 2013 Nov-Dec.

Abstract

Policy analysis shows that H. pylori test and treat strategies targeting adults at moderate to high risk of H. pylori-induced disease is likely to be cost-effective for preventing digestive diseases responsible for a large global disease burden. Little is known, however, about health benefits to children from eliminating this infection. We conducted a systematic review of the evidence regarding health benefits to children from treatment to eliminate H. pylori infection. We systematically searched Ovid MEDLINE for pertinent review articles published through 2012. We excluded reviews focused on treatment efficacy and scrutinized reference lists of selected reviews to identify additional eligible reviews. Fifteen reviews met specified inclusion criteria. Overall, they show that few reported studies investigating pediatric health effects of treatment for H. pylori infection were well designed with adequate statistical power. Thus, there is insufficient evidence for drawing conclusions about health benefits to children from treatment to eliminate H. pylori infection.

Keywords: Helicobacter pylori; benefit; child; prevention; treatment.

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References

    1. Torres J, Pérez-Pérez G, Goodman KJ, Atherton JC, Gold BD, Harris PR, la Garza AM, Guarner J, Muñoz O. A comprehensive review of the natural history of Helicobacter pylori infection in children. Arch Med Res. 2000;31:431–69. doi: 10.1016/S0188-4409(00)00099-0. - DOI - PubMed
    1. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000;22:283–97. doi: 10.1093/oxfordjournals.epirev.a018040. - DOI - PubMed
    1. Goodman KJ, Correa P. The transmission of Helicobacter pylori. A critical review of the evidence. Int J Epidemiol. 1995;24:875–87. doi: 10.1093/ije/24.5.875. - DOI - PubMed
    1. Goodman KJ, Cockburn M. The role of epidemiology in understanding the health effects of Helicobacter pylori. Epidemiology. 2001;12:266–71. doi: 10.1097/00001648-200103000-00023. - DOI - PubMed
    1. Elitsur Y, Yahav J. Helicobacter pylori infection in pediatrics. Helicobacter. 2005;10(Suppl 1):47–53. doi: 10.1111/j.1523-5378.2005.00332.x. - DOI - PubMed

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