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. 2009 Nov 18;1(1):3-11.
doi: 10.3390/cancers1010003.

BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas

Erica Lana  1 , Marie-Elisabeth Brun, Isabelle Rivals, Janick Selves, Sylvain Kirzin, Andriy P Lutsyk, Vasily V Gordiyuk, Frédéric Bibeau, Alla Rynditch, Albertina De Sario
Affiliations

BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas

Erica Lana et al. Cancers (Basel). .

Abstract

We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas. Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.

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Figures

Figure 1
Figure 1
DNA methylation percentages in five tissues. Data on paired colon cancer and healthy mucosas are from our previous study [6]; whereas data on adenomas are from this study (a different cohort of patients). T are tubulous, TV are tubulo- villous and V are villous adenomas.
Figure 2
Figure 2
Frequency of hypomethylated DNA (<42% according to [6]) and their 95% confidence intervals. Data in healthy mucosas and colon cancers are from [6]. T are tubulous, TV are tubulo- villous and V are villous adenomas.
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