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. 2010 May 28;2(2):1040-65.
doi: 10.3390/cancers2021040.

Biomarkers for Basal-like Breast Cancer

Jennifer R Choo  1 , Torsten O Nielsen
Affiliations

Biomarkers for Basal-like Breast Cancer

Jennifer R Choo et al. Cancers (Basel). .

Abstract

Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment.

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Figures

Figure 1
Figure 1
Immunohistochemical staining of a representative basal-like breast cancer using the definition of Nielsen et al. [5]. The case illustrated is ER negative, HER2 negative, EGFR strong positive and CK5/6 weak positive.
See this image and copyright information in PMC

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