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Review
. 2014 Jan;15(1):49-55.
doi: 10.1038/nrg3624. Epub 2013 Nov 26.

Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions

W Florian Fricke  1 , David A Rasko  1
Affiliations
Review

Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions

W Florian Fricke et al. Nat Rev Genet. 2014 Jan.

Abstract

The potential of bacterial whole-genome sequencing (WGS) to complement existing diagnostic infrastructures in clinical microbiology has been shown in proof-of-principle examples and extensively discussed. However, less attention has been drawn to bioinformatic challenges that are associated with the clinical adoption of WGS-based molecular diagnostics. This Perspective article discusses questions that are related to standard operating procedures, computational resource management, and data storage and integration in the context of recent developments in the sequencing and bioinformatics service markets.

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References

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