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. 2013;35(5):567-72.
doi: 10.1155/2013/183246. Epub 2013 Oct 27.

Tissue kidney injury molecule-1 expression in the prediction of renal function for several years after kidney biopsy

Sanja Simic Ogrizovic  1 , Suzana Bojic, Gordana Basta-Jovanovic, Sanja Radojevic, Jelena Pavlovic, Jelena Kotur Stevuljevic, Violeta Dopsaj, Radomir Naumovic
Affiliations

Tissue kidney injury molecule-1 expression in the prediction of renal function for several years after kidney biopsy

Sanja Simic Ogrizovic et al. Dis Markers. 2013.

Abstract

Objectives: Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy.

Materials and methods: Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.

Results: Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy.

Conclusion: Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.

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Figures

Figure 1
Figure 1
KIM-1 positive tubules are of intense red color. (a) Apical membrane of tubulocytes has the strongest affinity for KIM-1 specific antibodies. (b) Entire cytoplasm of tubulocytes has strong affinity for KIM-1 specific antibodies.
Figure 2
Figure 2
Linear correlation between TIN inflammation (P = 0.000), tissue KIM-1 expression (P = 0.000), and eGFR 6 months after kidney biopsy.
See this image and copyright information in PMC

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