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Review
. 2012 Mar;2(1):50-5.
doi: 10.3978/j.issn.2223-3652.2012.02.06.

Acute coronary syndrome in HIV patients: from pathophysiology to clinical practice

Enrico Cerrato  1 , Fabrizio D'Ascenzo, Giuseppe Biondi-Zoccai, Pierluigi Omedè, Claudio Moretti, Stefania Cicalini, Gurumurthy Parthasarathi, Imad Sheiban, Fiorenzo Gaita
Affiliations
Review

Acute coronary syndrome in HIV patients: from pathophysiology to clinical practice

Enrico Cerrato et al. Cardiovasc Diagn Ther. 2012 Mar.

Abstract

A majority of human immunodeficiency virus (HIV) infected subjects in developed countries have access to highly active anti-retroviral therapy (HAART), which is associated with significantly improved long term survival. In this setting, clinical attention needs to be focused on the impact of premature atherosclerotic cardiovascular disease (CVD), which already represents a leading cause of morbidity and mortality in these patients. While the higher prevalence of traditional risk factors remains the main culprit of increased CVD risk, HIV infection itself and antiretroviral toxicity are confounding proatherogenic factors. It is therefore critical to treat modifiable risk factors, keeping close attention to drug interactions in these patients with high cardiovascular risk profile.

Keywords: Acute coronary syndrome; highly active anti-retroviral therapy; human immunodeficiency virus.

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Figures

Figure 1
Figure 1
Pathogenesis of coronary artery disease (CAD) in HIV infection
See this image and copyright information in PMC

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