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. 2014 Aug;78(2):202-17.
doi: 10.1111/bcp.12293.

A systematic review of hospitalization resulting from medicine-related problems in adult patients

Abdullah Al Hamid  1 , Maisoon Ghaleb, Hisham Aljadhey, Zoe Aslanpour
Affiliations

A systematic review of hospitalization resulting from medicine-related problems in adult patients

Abdullah Al Hamid et al. Br J Clin Pharmacol. 2014 Aug.

Abstract

Aims: Medicine-related problems (MRPs) represent a major issue leading to hospitalization, especially in adult and elderly patients. The aims of this review are to investigate the prevalence, causes and major risk factors for MRPs leading to hospitalization in adult patients and to identify the main medicine classes involved.

Methods: Studies were identified through electronic searches of Medline, Embase, Scopus and International Pharmaceutical Abstracts between January 2000 and May 2013. A systematic review was conducted of both retrospective and prospective studies. Studies included were those involving hospitalization resulting from MRPs in adults (≥18 years old), whereas studies excluded were those investigating drug misuse and abuse and studies investigating MRPs in hospitalized patients. Data analysis was performed using SPSS version 20.

Results: Forty-five studies were identified, including 21 that investigated hospitalization resulting from adverse drug reactions, six studies that investigated hospitalization due to adverse drug events and 18 studies that investigated hospitalization due to MRPs. The median prevalence rates of hospitalization resulting from adverse drug reactions, adverse drug events and MRPs were 7% (interquartile range, 2.4-14.9%), 4.6% (interquartile range, 2.85-16.6%) and 12.1% (interquartile range, 6.43-22.2%), respectively. The major causes contributing to MRPs were adverse drug reactions and noncompliance. In addition, the major risk factors associated with MRPs were old age, polypharmacy and comorbidities. Moreover, the main classes of medicines implicated were medicines used to treat cardiovascular diseases and diabetes.

Conclusions: Hospitalization due to MRPs had a high prevalence, in the range of 4.6-12.1%. Most MRPs encountered were prevalent among adult patients taking medicines for cardiovascular diseases and diabetes.

Keywords: adult patient; adverse drug event; adverse drug reaction; hospitalization; medicine-related problem.

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Figures

Figure 1
Figure 1
Data extraction and study selection process. Abbreviations are as follows: ADEs, adverse drug events; ADRs, adverse drug reactions; MRPs, medicine-related problems
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References

    1. Bell J, Whitehead P, Aslani P, McLachlan T, Chen T. Drug-related problems in the community setting. Clin Drug Invest. 2006;26:415–425. - PubMed
    1. Fernandez-llimos F, Faus MJ, Gastelurrutia MA, Baena MI, Martinez FM. Evolution of the concept of drug-related problems?: outcomes as the focus of the new paradigm Evolución del concepto de problemas relacionados con medicamentos?: resultados como el centro del nuevo paradigma. Seguimieto Farmacoterapeutico. 2005;3:167–188.
    1. Pharmaceutical Care Network Europe (PCNE) 2006. Classification for drug related problems, Netherland; Available at http://www.pcne.org/sig/drp/documents/PCNE%20classification%20V5.01.pdf (last accessed 30 October 2013)
    1. Strand L, Morley P, Cipolle R, Ramsey R, Lamsam G. Drug-related problems: their structure and function. DICP. 1990;24:1093–1097. - PubMed
    1. Leendertse AJ, Egberts ACG, Stoker LJ, Van den Bemt PML. a. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168:1890–1896. doi: 10.1001/archinternmed.2008.3. - DOI - PubMed

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