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. 2014 Feb;19(1):16-21.
doi: 10.3109/1354750X.2013.863973. Epub 2013 Nov 28.

Evaluation of elevated urinary enolase I levels in patients with endometriosis

Bo Hyon Yun  1 , You Sun Lee, Seung Joo Chon, Yeon Soo Jung, Su Youn Yim, Hye Yeon Kim, Joo Hyun Park, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee
Affiliations

Evaluation of elevated urinary enolase I levels in patients with endometriosis

Bo Hyon Yun et al. Biomarkers. 2014 Feb.

Abstract

Objective: The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis.

Methods: Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine.

Results: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively.

Conclusion: Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis.

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