Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Dec 17;110(51):20356-7.
doi: 10.1073/pnas.1320032110. Epub 2013 Nov 27.

A symbiotic relationship between epithelial and stromal stem cells

Affiliations
Comment

A symbiotic relationship between epithelial and stromal stem cells

Andrew S Goldstein. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Reciprocal signaling between mouse prostate epithelial and stromal progenitor cells. Mouse prostate stromal cells signal to epithelium through Wnt ligands, fibroblast growth factors (FGFs), and transforming growth factor-β (TGF-β). Mouse prostate basal cells signal to a number of stromal cell-types through Sonic hedgehog.

Comment on

References

    1. Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: Stem cells and their niche. Cell. 2004;116(6):769–778. - PubMed
    1. Peng Y-C, Levine CM, Zahid S, Wilson EL, Joyner AL. Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration. Proc Natl Acad Sci USA. 2013;110:20611–20616. - PMC - PubMed
    1. Shen MM, Abate-Shen C. Molecular genetics of prostate cancer: New prospects for old challenges. Genes Dev. 2010;24(18):1967–2000. - PMC - PubMed
    1. Lawson DA, et al. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci USA. 2010;107(6):2610–2615. - PMC - PubMed
    1. Lu TL, et al. Conditionally ablated Pten in prostate basal cells promotes basal-to-luminal differentiation and causes invasive prostate cancer in mice. Am J Pathol. 2013;182(3):975–991. - PubMed

LinkOut - more resources