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. 2013 Nov 3:7:624-9.
doi: 10.2174/1874325001307010624. eCollection 2013.

In vitro elution characteristics of gentamicin and vancomycin from synthetic bone graft substitutes

Gerrit Steffen Maier  1 , Klaus Edgar Roth, Stefan Andereya, Klaus Birnbaum, Christopher Niedhart, Markus Lühmann, Jörg Ohnsorge, Uwe Maus
Affiliations

In vitro elution characteristics of gentamicin and vancomycin from synthetic bone graft substitutes

Gerrit Steffen Maier et al. Open Orthop J. .

Abstract

Objects: Beta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb(®) and Cerasorb M(®) was tested.

Methods: Antibiotic elution and concentration of gentamcin and vancomycin were measured using photometrically-based measurement and homogeneous particle-enhanced turbidimetric inhibition immunoassays (PETINIA).

Results: Initially both materials showed a high release of the loaded antibiotics, with Cerasorb M(®) showing lower release levels for gentamicin and vancomycin than Cerasorb(®). Gentamicin concentrations of Cerasorb M granules and Cerasorb were below the minimum detectiontreshold until day four and six of the experiment respectively. The vancomycin release-level followed a similar pattern, although the vancomycin concentration eluted by Cerasorb M(®) granules stayed above the detection threshold during the experimental time.

Conclusions: Cerasorb(®) and Cersorb M(®) may represent a new treatment option in osteomyelitis and infectious bone disease.

Keywords: Cerasorb M®; Cerasorb®; Osteomyelitis; beta tricalciumphosphate..

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Figures

Fig. (1)
Fig. (1)
Elution pharmacokinetics of Gentamicin from Cerasorb® and Cerasorb M®. Antibiotic release is expressed in μg /ml. Mean values were derived from a total of 4 different tests. Granules were loaded in a solution of 40 g/L antibiotics.
Fig. (2)
Fig. (2)
Elution pharmacokinetics of vancomycin from Cerasorb® and Cerasorb M®. Antibiotic release is expressed in μg /ml. Mean values were derived from a total of 4 different tests. Granules were loaded in a solution of 50 g/L antibiotic.
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