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Review
. 2013 Dec;42(4):697-719.
doi: 10.1016/j.ecl.2013.07.005.

Advanced glycation endproducts in diabetes and diabetic complications

Helen Vlassara  1 , Gary E Striker
Affiliations
Review

Advanced glycation endproducts in diabetes and diabetic complications

Helen Vlassara et al. Endocrinol Metab Clin North Am. 2013 Dec.

Abstract

This review presents insights from studies of advanced glycation end products (AGEs) in humans and mice. Although the emphasis is on the effects of exogenous AGEs and the suppression of specific host defense mechanisms, AGEs are also formed intracellularly, where they may contribute to several normal intracellular functions. It is only when the overall levels of AGEs in the extracellular and the intracellular spaces exceeds the ability of the native antioxidant (and AGE) defenses that they pose a problem.

Keywords: Advanced glycation endproduct; Diabetes; Insulin resistance; Metabolism.

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