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. 1986 Oct 15;38(4):489-94.
doi: 10.1002/ijc.2910380406.

Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney

E Oosterwijk, D J Ruiter, P J Hoedemaeker, E K Pauwels, U Jonas, J Zwartendijk, S O Warnaar

Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney

E Oosterwijk et al. Int J Cancer. .

Abstract

This report describes a monoclonal antibody designated G 250, subclass IgGl, that recognizes an antigen preferentially expressed on cell membranes of renal-cell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The staining pattern of G 250 differs from that of other RCC-related antibodies described. Preliminary experiments show that this antibody can be used to visualize RCC xenografts in nude mice by immunoscintigraphy.

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